9/1/2025
What Everyone Should Be Doing For Their Health
Make sure you're keeping up with the basics.
8/15/2025
What to Do About SSRI Withdrawal Mitochondrial Dysfunction
The final installment in our series on understanding the truth about SSRIs.
8/1/2025
This Is 25x More Effective Than Antidepressants—And It's Not a Drug
In this article we will examine a potential treatment for depression that so far looks to be almost 25 times more effective than antidepressants and four times more effective than ketamine at creating long-term psychological resilience.
7/29/2025
SSRIs Can Cause Severe Mitochondrial Dysfunction
In at least one out of 5,500 people – possibly at a much higher rate due to ignorance and underdiagnosis – sertraline (Zoloft) is such a potent mitochondrial poison that it can induce a devastating disease that has heretofore been thought to be a much rarer genetic disorder.
7/21/2025
SSRI Withdrawal Is Mitochondrial Dysfunction
In analyzing the biochemical data of clients over the last year I have worked on two cases involving catastrophic failures of energy metabolism that occurred in the wake of SSRI withdrawal. In both cases, switching SSRIs from one to another also seemed to play a role in precipitating energetic dysfunction.
7/13/2025
SSRIs are Mitochondrial Drugs
These not only interact with the ability of serotonin and melatonin to support mitochondrial function in both good and bad ways, but are themselves drugs that act on mitochondria both by activating receptors that have little to do with serotonin inside cells and by traveling to the mitochondria and having variable effects that are mostly toxic.
7/12/2025
Your Mitochondria and the Two Faces of Serotonin
In our series on how to understand the truth about serotonin, SSRIs, SSRI side effects, and the sometimes devastating effects of SSRI withdrawal, we have so far established that serotonin is a primarily non-brain non-neuronal signaling chemical that is fundamentally involved in the hypoxia response, and is also the substance from which we make melatonin, our mitochondria’s guardian angel.
1/29/2024
The Mitochondrial Nutrient Missing From Every Supplement
It's the respiratory chain component you never learned about in school.
4/28/2023
A PhD's Secret Weapon: The Four Biomarkers Every Expert Should, But Doesn’t, Analyze
The most useful tests are the ones no one ever orders.
6/23/2024
Your Cells Are Starving for Creatine
If you're not eating this type of diet you need a supplement.
5/23/2024
You Don't Understand Serum Ferritin
Neither does your doctor, and neither do I. But here's what we all don't know.
7/1/2023
The Guide to Methylene Blue
A 51-page guide on everything you need to know about methylene blue.
9/27/2025
Beat Depression Without SSRIs or Other Drugs
The ultimate how-to guide to obtain resilient mental health while boosting mitochondrial function instead of strangling it.
10/6/2025
The Science Behind The Depression Protocol
Hundreds of randomized controlled trials show that non-drug approaches are superior to drugs. Here's the evidence.
10/8/2025
Are Antidepressants Just Treating Protein Deficiency?
This one amino acid outperforms antidepressant drugs in clinical trials but protein itself would be even better.
11/3/2025
Resolve Your Inflammation With This
One of the most promising natural resolvers of inflammation is a milk-derived protein known as lactoferrin.
As we will see momentarily, however, not all lactoferrin is created equal.
11/4/2025
Masterjohn’s Weekly Five
Edition 1: Pharma vs Nature, lima beans, common problems driven by rare bottlenecks, hiding the control group, and bonk-free marathons fueled by chocolate.
9/12/2025
3 Tests to Transform Your Health (and Your Lifespan)
If there are still things you want to improve about your current health or that you want to optimize to protect your future health and longevity, it may be time to do some lab testing beyond whatever your doctor orders for you in your checkups.
3 Tests to Transform Your Health (and Your Lifespan)
If there are still things you want to improve about your current health or that you want to optimize to protect your future health and longevity, it may be time to do some lab testing beyond whatever your doctor orders for you in your checkups.
11/25/2025
The science that convinced me mitochondria are the key to longevity
You could be one metabolic bottleneck away from feeling amazing.